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PRMT1 loss sensitizes cells to PRMT5 inhibition

(F) Using total cell lysates from MTAP-deleted and MTAP-rescued cells, the levels of SDMA, ADMA, SmB methylation (Y12) and MTAP were analyzed by western blot. To investigate possible phenotypes or behaviors that distinguish the MCF-7 cell line from the other three lines, we examined the MTAP copy number and PRMT5 dependency in 646 cancer cell lines from the DepMap project ( 37 ) (Figure 4E ).

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Symmetric multiprocessing (SMP) involves a multiprocessor computer hardware and software architecture where two or more identical processors are connected to a single, shared main memory, have full access to all input and output devices, and are controlled by a single operating system instance that treats all processors equally, reserving none for special purposes.

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